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• Sales Rank: #3390950 in Books
• Published on: 2005-08-18
• Ingredients: Example Ingredients
• Binding: Paperback

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• Published on: 2005-11-01
• Format: Import
• Original language: English
• Binding: Hardcover
• 256 pages

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• Sales Rank: #1526967 in Books
• Published on: 2015-08-01
• Original language: English
• Number of items: 1
• Dimensions: 9.02" h x .38" w x 5.98" l, .0 pounds
• Binding: Paperback
• 166 pages

About the Author
Harris Kern is one of the world’s leading organization and personal mentors www.disciplinementor.com. He is a frequent speaker and seminar leader at business, leadership and management conferences. His passion is to help people excel in their professional and personal life by helping them develop their self-discipline skills to combat the top issues: severe procrastination, poor time management, ineffective goal management, lack of focus, no sense of urgency and unmotivated. He also helps individuals improve their EQ skills (communication, relationship management, inter-personal, etc.) and leadership skills. He pioneered the Discipline Mentoring Program and Professional/Personal Growth Program (P²GP). Mr. Kern is also the author of over 40 books, some of the titles include: DISCIPLINE: Six Steps To Unleashing Your Hidden Potential, DISCIPLINE: Training The Mind To Manage Your Life, DISCIPLINE: Mentoring Children For Succes, and DISCIPLINE: Take Control of Your Life. Mr. Kern is recognized as the foremost authority on providing practical guidance for solving management issues and challenges. He has devoted over 30 years helping professionals build competitive organizations. His client list reads like a who’s who of American and International Business. His client list includes Standard and Poor’s, GE, The Weather Channel, NEWS Corporation, Hong Kong Air Cargo Terminal (HACTL), among hundreds of other Fortune500 and Global 2000 companies. Mr. Kern is the founder and driving force behind the Enterprise Computing Institute www.harriskern.com and the best-selling series of books published by Prentice Hall. As founder of the Enterprise Computing Institute, he has brought together the industry's leading minds to publish "how-to" textbooks on the critical issues the IT industry faces. The series includes titles such as: IT Services, IT Organization, High Availability, CIO Wisdom, CIO Wisdom II, and Managing IT as an Investment, among others. Mr. Kern’s goal is to arm individuals and organizations with the tools to empower them to become more productive and successful. (Harris Kern)

Most helpful customer reviews

1 of 1 people found the following review helpful.
You never seize to amaze me. And thank you for inspiring and guiding ...
By Donna Incorvaja
Harris Kern is no new name to us anymore. He has touched so many people in so many different ways with his wise words through script. I have to say I read and follow Harris Kern as I am a big fan and he truly helped me take myself to the next level. But i have to say that this book is slightly different. It not only mentors you but makes you reflect more on what life is all about. I purchased the book a few weeks ago and once i started reading it i couldnt take it off my hands until i saw the back cover. Well done Harris Kern. You never seize to amaze me. And thank you for inspiring and guiding us. Looking forward to your next book as always.

1 of 1 people found the following review helpful.
This book is a good wakeup call
By Amazon Customer
Very insightful and although at first I was skeptical about reading another self-help book, because I have read a few and years later I am still procrastinating and not always motivated to work on my goals. I tried using the author's anecdote by training my mind to live with urgency and it really helped me a lot. I learned quite a bit about holding yourself accountable in the author's previous book, but this one provides more details and is dedicated to helping you get off your butt and making something happen quickly before another ten years fly by and you haven't accomplished anything. This book is a good wakeup call. art

1 of 1 people found the following review helpful.
Another Winner
By Charles Sickels
Outstanding, Harris Kern has done it again with his new book "Live Like You Are Dying"! This time he has written a book that is a clarion call to both young and old to get their a**s in gear, because time waits for no one. This book is chuck full of wisdom on how to accomplish more in your life in a shorter period of time, "before it's too late". :-) Throughout the book Harris doesn't hesitate to make all of his successes AND failures available to the reader as examples of what to do and what not to do in fufilling your goals. Harris will coach you all along the way as to what it will take to reach all of your goals, but he won't hold your hand or tolerate any excuses, in fact he covers almost any excuse that you can come up with, he's heard them all. Me, being a senior citizen, (did I just admit that? LOL) I need all of the help that I can get because time IS running out for me, and this book has all that I need to reach all of my goals.

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• Sales Rank: #7037964 in Books
• Published on: 2004-01
• Original language: Spanish
• Number of items: 1
• Dimensions: 1.00" h x 7.86" w x 10.24" l,
• Binding: Paperback
• 509 pages

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• Sales Rank: #9177125 in Books
• Published on: 2000-11-30
• Original language: English
• Number of items: 1
• Binding: Hardcover
• 160 pages

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• Original language: German, English
• Dimensions: 9.69" h x .51" w x 7.48" l,
• Binding: Paperback

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Charles A. Bear’s An Economic Interpretation of the United States Constitution was a work of such powerful persuasiveness as to alter the course of American historiography. No historian who followed in studying the making of the Constitution was entirely free from Beard’s radical interpretation of the document as serving the economic interests of the Framers as members of the propertied class. Forrest McDonald’s We the People was the first major challenge to Beard’s thesis. This superbly researched and documented volume restored the Constitution as the work of principled and prudential men. It did much to invalidate the crude economic determinism that had become endemic in the writing of American history.

We the People fills in the details that Beard had overlooked in his fragmentary book. MacDonald’s work is based on an exhaustive comparative examination of the economic biographies of the 55 members of the Constitutional Convention and the 1,750 members of the state ratifying conventions. His conclusion is that on the basis of evidence, Beard’s economic interpretation does not hold. McDonald demonstrates conclusively that the interplay of conditioning or determining factors at work in the making of the Constitution was extremely complex and cannot be rendered intelligible in terms of any single system of interpretation.

McDonald’s classic work, while never denying economic motivation as a factor, also demonstrates how the rich cultural and political mosaic of the colonies was an independent and dominant factor in the decision making that led to the first new nation. In its pluralistic approach to economic factors and analytic richness, We the People is both a major work of American history and a significant document in the history of ideas. It continues to be an essential volume for historians, political scientists, economists, and American studies specialists.

• Sales Rank: #455284 in Books
• Published on: 1991-01-01
• Original language: English
• Number of items: 1
• Dimensions: 9.02" h x 1.03" w x 5.98" l, 1.39 pounds
• Binding: Paperback
• 455 pages

About the Author

Forrest McDonald is Distinguished University Research Professor of History at the University of Alabama at Tuscaloosa. He is the author of many books on American history including A Constitutional History of the United States, E Pluribus Unum, and Novus Ordo Seclorum: The Intellectual Origins of the Constitution.

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32 of 43 people found the following review helpful.
The Debunker Debunked
By Kurt J. Acker
Here's why this book was written: In 1913, Columbia University History Professor, Charles Beard, published "An Economic Interpretation of the Constitution." Beard's thesis was straight out of Karl Marx: The US Constitution was designed, written and ratified - Beard told his readers - not to secure the welfare of the American people as a whole, but for no other purpose than to safeguard the wealth and privilege of a propertied elite. Beard's message was somewhat shocking; it was also totally wrong. But in the absence of rebuttal, it became the conventional wisdom for the next 50 years - that is, until 1958, when Forrest McDonald's "We the People" blew Beard's argument out of the water.

In the simplest terms, Beard saw the Constitution as the product of a fierce class-struggle between two interest groups, one agrarian, the other mercantile. The first of these were mainly small farmers, often in debt, in favor of paper money and stay-laws, dominant in the state legislatures - in Beard's scheme, the "good guys". The second were merchants and speculators in war bonds, people who favored creditor's rights and a strong central government - these were the "bad guys". Beard's sketchy research seemed to confirm his hunch that those who supported the Constitution, whether at the Convention or later in the process of ratification, came from the mercantilist group. Thus his conclusion: the US Constitution is "an economic document drawn with superb skill" and foisted on a largely agrarian country by a clever, monied elite.

Exploding this theory turned out to be child's play. McDonald collected a lot of data that Beard never considered. And this data showed that in reality, most supporters of the Constitution were NOT people with mercantile interests, but rather those who owned farms. In other words, the people Beard imagined as victims of the new order - actually threw their support behind it! For example, 77% of the Delaware delegation, which voted unanimously to ratify, were farmers and 2/3 of those were small farmers with low incomes. Even in Connecticut, where mercantile interests were strong, 75% of farmers voted in favor of ratification. So much for Beard!

How did Beard get it so wrong? Among other things, his simplistic analysis obscured differences in the economic interests of various subgroups of mercantilists and agrarians. Thus he ignored many of the economic factors that actually motivated the delegates and missed the fact that many farmers had something to gain from the Constitution, just as some merchants had something to lose.

McDonald doesn't deny that economic motives are important to the analysis of history. On the other hand, "no single system of interpretation (economic or otherwise) can explain all historical phenomena"; an adequate explanation requires that "countless noneconomic factors be taken into consideration."

One cannot do justice to McDonald in a short review. The book is superb and is recommended for anyone interested in constitutional history.

6 of 6 people found the following review helpful.
Discrediting a Fallacy
By Ricardo Mio
“This summer, when you become inundated with all the American bicentennial Fourth-of-July brouhaha, don’t forget you’re celebrating the fact that a bunch of slave-owning aristocratic white males who didn’t want to pay their taxes.” The line is from the 1977 movie “Dazed and Confused,” spoken by a high school teacher as she dismisses her class for the summer. It’s outrageous and funny, but it reflected the attitude of some of my college professors back in the late ’60 and early ‘70s.

That attitude reverberated in the halls of academia like the echo that still reverberates in outer space from the Big Bang that gave birth to the universe. In the case of liberal academia, the Big Bang that gave birth to the idea that the Founding Fathers were little more than money-grubbing hucksters who wrote the U.S. Constitution as a means of securing their fortunes, was from a book by a Columbia professor named Charles A. Beard. Published in 1913, the book was titled “An Economic Interpretation of the United States Constitution.” Beard’s radical interpretation was immediately accepted as gospel among academics and in time began to find its way into American history textbooks. However, if anyone had examined the flimsy scholarship behind Beard’s arguments, they would have discovered a host of oversights and errors. Indeed, a good part of Beard’s scholarship was not scholarship at all, but rather a series of assumptions based on questionable evidence that supported his theory. Why was the book accepted without question by academia? Probably because it came at a time when American capitalism was being questioned for the first time, especially in the wake of the robber barons and their blatant exploitation and abuse of American factory workers prior to the rise of labor unions. Indeed, Beard’s book was published when socialism was on the rise and talk among the intelligentsia was of class struggle between the working class and private industry. Two decades later the Depression set in, yet another sign that capitalism was failing American workers, furthering strengthening Beard’s interpretation.

Not everyone in academic circles bought Beard’s interpretation or believed socialism was the answer to the plight of the working class. Opposition among academics was mounting. In 1944, Frederick Hayek published “The Road to Serfdom” that presented a strong and well-reasoned case against socialism. Capitalism fosters democracy, said the author, and (quoting Tocqueville) “democracy seeks equality in liberty, socialism seeks equality in restraint and servitude.” Similar writers and thinkers included Russell Kirk, Richard Weaver and Douglas Adair. In 1948, a graduate student from the University of Texas named Forrest McDonald set out to disprove Beard’s thesis by going directly to the source. He made a tour of the East Coast, digging into the actual financial records of America between 1776 and 1790. He made the rounds of all the various repositories: the Library of Congress, state archives and historical societies, and a number of libraries that had collected great quantities and catalogued them. By the end of his three-year research, he not only had more than enough evidence to invalidate Beard’s thesis as fanciful scholarship, he had his hand on the financial pulse of the early American Republic. He knew who owned what and how much, what they paid for it and what they sold it for, not only in federal and state securities, but in real estate, from the smallest dirt farmer in New England, to the largest slave plantation owner in the Deep South. Lawyers, judges, merchants, tradesmen, physicians, ministers, innkeepers, tavern keepers, surveyors, farmers, planters, no matter their occupation or position of influence—if they dealt in land speculation or traded in stocks, McDonald knew about it. McDonald wrote about his findings, published in 1958, in a book entitled “We the People: The Economic Origins of the Constitution.”

“What I objected to about Beard’s thesis,” writes McDonald in the introduction, “was not its emphasis upon the previously neglected role of economics but its simplistic determinism, its omission of the power factor, and its unwillingness to consider that the Constitution was the work of principled and prudential men.” The facts McDonald recovered did not substantiate Beard’s assumptions; the details were found to be incompatible with the broad outlines he sketched. “Beard asked the wrong questions,” said McDonald, “questions which, in the way they were phrased, were meaningless. The Philadelphia Convention, as a body, was acting neither as ‘a consolidated economic group’ nor ‘merely under the guidance of abstract principles of political science.’ The contest over ratification was neither an economic class struggle nor ‘the product of some abstract causes remote from the chief business of life—gaining a livelihood.’ By asking invalid questions Beard arrived at an interpretation that obscures rather illumines the role of economic forces in the making of the Constitution.”

Most of the delegates to the Constitutional Convention made their decisions on the basis of what they took to be the general welfare of Americans, McDonald concluded, rather than to secure or enhance their economic and/or social advantage. Not all holders of public securities favored the new Constitution, as Beard would have us believe. Indeed, a number of the largest holders who stood to greatly enhance their investment should the Constitution be ratified, actually worked against ratification. Another of Beard’s myths was that only a privileged few actually benefited from the sale of public securities after ratification, while McDonald’s evidence revealed people from all walks of life making money from their sale. George Mason, one of the wealthiest men in America (and George Washington’s neighbor) fought against ratification because the Constitution did not have a bill of rights, as did many other wealthy landowners both north and south of the Mason-Dixon line. The facts are the facts, and the facts revealed that most people acted from principles they held dear rather than from properties they held dear. The latter part of McDonald’s book contains a fair amount of the financial data McDonald uncovered, including a multitude of differing economic factions that fueled the American Revolution and drove the nation’s economy and, despite their regional and social differences, created a national government that survives to this day.

Final note: there was a backlash among liberal academia when McDonald’s book was published—they stuck by their man despite irrefutable evidence that as far as historical accuracy, he was wrong, wrong, wrong. Beard’s book still sells but now it has an intro by Forrest McDonald who, while respectful, sets the record straight.

2 of 2 people found the following review helpful.
MCDONALD'S CRITIQUE OF CHARLES BEARD'S "ECONOMIC INTERPRETATION OF THE CONSTITUTION"
By Steven H Propp
Forrest McDonald (born 1927) is an American historian, who has also written books such as E Pluribus Unum: The Formation of the American Republic 1776-1790. and Novus Ordo Seclorum: The Intellectual Origins of the Constitution [Paperback]. This book was originally published in 1958, and revised in 1992.

This book is a response to Charles A. Beard's An Economic Interpretation of the Constitution of The United States [Paperback]. McDonald wrote in the Preface, "The purpose of the present work is to examine Beard's thesis as history... I believe that by examining Beard's system of interpretation as history something of a fundamental nature can be learned about the process of attempting to understand history."

He notes, "the delegates on the two sides held about the same amounts of the same kinds of property... If the differences in the property holdings of the members are of any significance whatever, they tend to indicate that the exact opposite of Beard's thesis is more nearly the truth than the thesis itself." (Pg. 181-182) Later, he observes that "a large number of delegates who could expect to derive economic gain from the adoption of the Constitution voted against ratification." (Pg. 189)

He argues that "Study of the economic backgrounds of the personnel of the ratifying convention leads to the conclusion that economic considerations could have had little weight in determining the decision of most members of the convention." (Pg. 246) He concludes, "the property holdings of ratificationists and anti-ratificationists were virtually identical except that more small farmers from the interior supported ratification than opposed it." (Pg. 268)

He summarizes, "Beard's thesis is entirely incompatible with the facts. Beard's essential error was in attempting to formulate a single set of generalizations that would apply to all the states." (Pg. 357) Nonetheless, he concedes, "in several instances economic factors were by no means without influence in the making of the Constitution. On the contrary, in several instances economic elements were obviously of considerable importance." (Pg. 358)

Whether one liked Beard's thesis or not, this book is an essential one for any student of the origin of our nation.

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This Quick Guide covers aspects of drug assessment at the drug discovery and development stages, including pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations.

• Sales Rank: #1156084 in Books
• Published on: 2011-04-19
• Released on: 2011-04-19
• Original language: English
• Number of items: 1
• Dimensions: 8.00" h x .52" w x 5.00" l, .55 pounds
• Binding: Paperback
• 214 pages

Review

From the reviews:

“The authors have to be complimented with this comprehensive book of reference on various important topics in the field of pharmacokinetics and drug metabolism. It contains a large collection of figures and tables providing relevant and well-organized information. … In conclusion, this is a valuable reference for workers in the field of pharmacokinetics and drug metabolism, providing a storehouse of information in a comprehensive book.” (Johannes H. Proost, International Journal of Clinical Pharmacology and Therapeutics, Vol. 50 (6), June, 2012)

“The authors intend the book to inform important decisions in a timely fashion ‘for synthesis of superior compounds that have the potential for being a safe and effective drug’. The summary format was designed to be clear, concise and self-explanatory, so it could be used on a daily basis to inform those design decisions. It achieves this goal. It is intended for all drug-discovery scientists, and researchers in all disciplines will certainly find it useful. … In summary, this is a valuable little book.” (Andy Davis, ChemMedChem, Vol. 7, 2012)

“This guide can be used on a day-to-day basis as a useful reference for almost anyone, including students first learning these concepts, as well as scientists in the pharmaceutical industry hoping to apply these principles in their research. … This is a nicely organized quick reference on basic concepts in pharmacokinetics and drug metabolism. It will be a useful addition to the libraries of a variety of readers, from students in the pharmaceutical sciences to accomplished researchers in drug development.”­­­ (Melissa M. Ranieri, Doody's Book Reviews, December, 2011)

From the Back Cover

Drug Metabolism and Pharmacokinetics Quick Guide is intended for broad readership of those interested in the discipline of drug metabolism and pharmacokinetics who work in drug discovery coming from the various disciplines, a background such as of medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics or toxicology.

This guide provides, for the first time, a completely integrated look at multiple aspects of absorption, distribution, metabolism, and excretion (ADME) science in a summary format that is clear, concise and self-explanatory.

This book will be used and referenced frequently as it provides detailed figures and tables for data interpretation. Also included are brief yet relevant factoids that bring a real-world dimension to the discussion of drug metabolism and pharmacokinetics.

Key topics covered:

1. Pharmacokinetics

2. Drug metabolizing enzymes

3. Oral absorption

4. Transporters

5. Metabolism-based drug interactions

6. Biotransformation and bioactivation

7. Prediction of human pharmacokinetics

8. Bioanalysis

9. Physicochemical properties and drug-like properties

10. In silico tools

11. Approved drugs

12. Chemical nomenclature

About the Author

Dr. Siamak Cyrus Khojasteh received his BS from University of California at Berkeley and his PhD from University of Washington in Medicinal Chemistry under the direction of Dr. Sidney D. Nelson.  Dr. Khojasteh leads the Metabolism efforts at Genentech (South San Francisco) and leads a team of about 20 scientists and prior to that he was a Senior Research Scientist at Pfizer (Groton, CT).  His research interest is mechanism of biotransformation particularly with formation of reactive metabolites by P450 or non-P450 enzymes.  

 

Harvey Wong graduated from the University of British Columbia with a Ph.D. in Pharmacokinetics and Biopharmaceutics.  Following graduation, he worked at the DuPont Pharmaceutics Company followed by Bristol-Myers Squibb in the area of Neuroscience Drug Discovery.  Currently, Harvey is a Senior Scientist in the Department of Drug Metabolism and Pharmacokinetics at Genentech, Inc. working in the areas of oncology and immunology.  He is involved in pharmacokinetic modeling and defining preclinical PK-PD relationships for drug candidates in both therapeutic areas. Harvey has published over 70 publications and abstracts.

 

Dr. Cornelis E.C.A. Hop is supervising the Small Molecule Drug Metabolism & Pharmacokinetics Department at Genentech (South San Francisco) and leads a team of about 55 scientists involved in acquisition and interpretation of ADME data in support of drug discovery and development.  Before that he was a senior director at Pfizer (Groton, CT) and a Senior Research Fellow at Merck (Rahway, NJ).  Dr. Hop has extensive experience in ADME sciences and biotransformation, PK prediction and bioanalysis in particular.  He has authored more than 100 publications in refereed journals and several book chapters and made more than 50 external oral presentations at conferences and universities.

Most helpful customer reviews

3 of 4 people found the following review helpful.
Great comprehensive and compact guide
By Amazon Customer
Wonderful guide, very useful as a quick reference or crash course in DMPK. Great coverage of important concepts, thoughtfully written an assembled, and easy to follow for those of us without formal training in pharmacokinetics.

0 of 0 people found the following review helpful.
Quick guide indeed
By nPe
If you wanted to get a start on DMPK, this is an awesome jumping off point. Accurate, current, easy to read and a convenient size for ready access. Wish there was an 'app' like this...

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